When you do it you will have to completely evac the AC system. Its not a really hard job, but the radiator will have to be moved out of the way.
As far as seals, there are a few rubber o rings that I will usually replace when doing condensers as a safe measure, but sometimes you can get away without replacing them.
You will be able to run the car without freon in it. It won't hurt anything. Your AC just won't work
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